The article uses the hg38 reference genome for its analyses. My question is: can I perform the conversion using reference genomes from other human populations or specific ethnic groups instead?
Hi There!
Thanks for reaching out.
Yes you can into a genomic sequence and use predict_sequence. The benefit of predict_interval is that it uses the gene annotations of the reference, which is important for some of the scoring methodologies employed by score_variant. The gene annotation are also really helpful for plotting purposes. I recommend you use a coordinate conversion tool like liftover to move from (eg) hg19 to hg38.
Kind regards,
Tumi