Inquiry regarding availability of precomputed whole-genome output tracks

Help & Support
1

Hi AlphaGenome Team,

I was wondering if there are any precomputed track outputs available for download for the reference human genome (hg38). I came across the roundtable discussion and noted that precomputing variant scores is something currently being explored.

In particular, I was curious whether resources such as precomputed decoder outputs or chromatin accessibility tracks are available.

Thank you!

2

Hi There!

Thanks for reaching out.

Currently, precomputed track outputs or static data results are not available for download.

However, as mentioned in the round table, the team is considering adding precomputed variant scores to the longer-term roadmap and plans to keep users updated on any new developments.

Kind regards,
Tumi

3

@Tumi_Makgatho Any updates on the progress of this? Most in the Human Genetics community find it hard to see utility in a tool that you can only annotate a few variants at a time via an API. When having the pre-computed values you can annotate a large WGS data set pretty quickly and efficiently. At the moment the tool isn’t very useful to analyze genomes without having pre-computed values even if it’s relative to the reference genome.

On my wish list are splicing scores. The competing tools such as SpliceAI and Pangolin have these values that are easily downloadable and efficiently utilized in genomics annotation pipelines.

4

Hi There!

Thanks for reaching out and sharing your feedback regarding the utility of precomputed tracks for large-scale datasets.

Unfortunately, we have no new updates or specific timelines that we can share at the moment.

Kind regards,
Tumi