This looks like a networking issue, are you able to download https://storage.googleapis.com/alphagenome/data/hg38/calibration_scores.pb ?
if you don’t need calibrated scores when running the OSS model, you can disable by overriding the path on construction like so:
import dataclasses
from alphagenome_research.model import dna_model
organism_settings = dna_model.default_organism_settings()
# Set calibration path to None.
organism_settings[dna_model.Organism.HOMO_SAPIENS] = dataclasses.replace(
organism_settings[dna_model.Organism.HOMO_SAPIENS], calibration_path=None
)
model = dna_model.create_from_huggingface(
'all_folds', organism_settings=organism_settings
)