# How to change the reference genome?

**URL:** <https://www.alphagenomecommunity.com/t/how-to-change-the-reference-genome/319>\
**Category:** Help & Support\
**Created:** [July 2, 2025, 7:58am UTC](https://www.alphagenomecommunity.com/t/how-to-change-the-reference-genome/319 "2025-07-02T07:58:10Z")\
**Posts on this page:** 5\
**Page:** 1

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**Author:** ![Animesh\_Kumar\_Singh](https://yyz2.discourse-cdn.com/watermelon/user_avatar/www.alphagenomecommunity.com/animesh_kumar_singh/32/271_2.png) [@Animesh\_Kumar\_Singh](https://www.alphagenomecommunity.com/u/Animesh_Kumar_Singh)\
**Post date:** [July 2, 2025, 7:58am UTC](https://www.alphagenomecommunity.com/t/how-to-change-the-reference-genome/319/1 "2025-07-02T07:58:10Z")

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Is it possible to change the reference genome? I believe default human genome is hg38, is it possible to change it to hg19.

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**Author:** ![Joshua\_Pan](https://yyz2.discourse-cdn.com/watermelon/user_avatar/www.alphagenomecommunity.com/joshua_pan/32/206_2.png) [@Joshua\_Pan](https://www.alphagenomecommunity.com/u/Joshua_Pan)\
**Post date:** [July 2, 2025, 3:09pm UTC](https://www.alphagenomecommunity.com/t/how-to-change-the-reference-genome/319/2 "2025-07-02T15:09:19Z")

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No, it is not possible to change the reference genome for human. However, tools like liftover, can be used outside of our API, to convert hg19 coordinates to hg38.

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**Author:** ![Claus\_Volko](https://yyz2.discourse-cdn.com/watermelon/user_avatar/www.alphagenomecommunity.com/claus_volko/32/255_2.png) [@Claus\_Volko](https://www.alphagenomecommunity.com/u/Claus_Volko)\
**Post date:** [July 3, 2025, 3:05pm UTC](https://www.alphagenomecommunity.com/t/how-to-change-the-reference-genome/319/3 "2025-07-03T15:05:24Z")

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The LiftOver tool can be accessed via: [https://genome.ucsc.edu/cgi-bin/hgLiftOver](https://genome.ucsc.edu/cgi-bin/hgLiftOver)

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**Author:** ![CameronDWills](https://yyz2.discourse-cdn.com/watermelon/user_avatar/www.alphagenomecommunity.com/camerondwills/32/67_2.png) [@CameronDWills](https://www.alphagenomecommunity.com/u/CameronDWills)\
**Post date:** [July 3, 2025, 11:34pm UTC](https://www.alphagenomecommunity.com/t/how-to-change-the-reference-genome/319/4 "2025-07-03T23:34:06Z")

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I’m working on a tool that’s powered by AlphaGenome and lets you use all of the AlphaGenome features in a GUI, amongst other things. One of the features it has is the ability to automatically translate hg19 to hg38, as well as mm9 to mm10 😁

It’ll be free of course, and open source. I’m almost done, trying to get it done by this weekend. Will share it here with the community when it’s ready!

 ![Screenshot 2025-07-03 164612](https://canada1.discourse-cdn.com/watermelon/original/1X/87fa828449fb065bff86d721f4852c58436c1797.jpeg)

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**Author:** ![Yusen\_Hou](https://yyz2.discourse-cdn.com/watermelon/user_avatar/www.alphagenomecommunity.com/yusen_hou/32/325_2.png) [@Yusen\_Hou](https://www.alphagenomecommunity.com/u/Yusen_Hou)\
**Post date:** [July 9, 2025, 6:25am UTC](https://www.alphagenomecommunity.com/t/how-to-change-the-reference-genome/319/5 "2025-07-09T06:25:00Z")

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Hi, Cameron. Your work looks very cool. I wanna know when you will release this GUI? Thanks in advance!