# AlphaGenome public URL/ running AG in R

**URL:** <https://www.alphagenomecommunity.com/t/alphagenome-public-url-running-ag-in-r/694>\
**Category:** Feedback & Feature Requests\
**Created:** [October 17, 2025, 6:19pm UTC](https://www.alphagenomecommunity.com/t/alphagenome-public-url-running-ag-in-r/694 "2025-10-17T18:19:52Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![Tee\_Dee](https://yyz2.discourse-cdn.com/watermelon/user_avatar/www.alphagenomecommunity.com/tee_dee/32/569_2.png) [@Tee\_Dee](https://www.alphagenomecommunity.com/u/Tee_Dee)\
**Post date:** [October 17, 2025, 6:19pm UTC](https://www.alphagenomecommunity.com/t/alphagenome-public-url-running-ag-in-r/694/1 "2025-10-17T18:19:52Z")

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Does AlphaGenome have a public URL? I am interested in running AlphaGenome in R, but cannot find the API endpoint to perform the get requests from.

Is this information disclosed? Can I run AG in R?

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**Author:** ![tward](https://yyz2.discourse-cdn.com/watermelon/user_avatar/www.alphagenomecommunity.com/tward/32/17_2.png) [@tward](https://www.alphagenomecommunity.com/u/tward)\
**Post date:** [October 18, 2025, 5:16pm UTC](https://www.alphagenomecommunity.com/t/alphagenome-public-url-running-ag-in-r/694/2 "2025-10-18T17:16:16Z")

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Hello @Tee_Dee,

So AlphaGenome is built on [gRPC](https://grpc.io) and, due to the potentially large size of predictions, utilizes its [streaming protocol](https://grpc.io/docs/what-is-grpc/core-concepts/#bidirectional-streaming-rpc).

The URL we connect to is [gdmscience.googleapis.com:443](http://gdmscience.googleapis.com:443) (see [here](https://github.com/google-deepmind/alphagenome/blob/29ef231db14f06edca170692a1e6bd78070156c5/src/alphagenome/models/dna_client.py#L915)), but I don’t believe there’s any official support for gRPC in R, so you might find it difficult to make direct GET requests.

Hope this helps and I do hope you manage to find a way: I’m sure there’s plenty of researchers who would be thankful of a means to run AlphaGenome in R!